IL-31 antibody therapy is a treatment option for which canine condition?

• A. Dermatitis
• B. Osteoarthritis
• C. Diabetes mellitus
• D. Hypothyroidism

Answer: (A)

IL-31 antibody therapy treats dermatitis in dogs by neutralizing a key itch-promoting cytokine. IL-31 is involved in signaling that triggers pruritus in allergic skin disease, so blocking it with a targeted antibody reduces itching and improves comfort without broad immune suppression. This approach specifically addresses dermatitis, not conditions like osteoarthritis, diabetes mellitus, or hypothyroidism, which involve different disease mechanisms and aren’t driven by IL-31 signaling.