Short-acting glucocorticoids have a duration of less than how many hours?

• A. Less than 12 hours
• B. Less than 24 hours
• C. Less than 6 hours
• D. Less than 48 hours

Answer: (A)

Short-acting glucocorticoids are defined by a duration of action that lasts only part of the day. The typical duration is about 8 to 12 hours, so the conventional cut-off is less than 12 hours. Hydrocortisone is a classic example, providing effects for roughly half a day and often requiring divided dosing to cover daily needs. In contrast, intermediate-acting steroids like prednisone or methylprednisolone last longer, around 12 to 36 hours, and long-acting ones such as dexamethasone extend beyond 36 hours. So, the statement that short-acting glucocorticoids have a duration of less than 12 hours best fits their standard classification.