What is the reversal agent for benzodiazepines?

• A. Flumazenil
• B. Naloxone
• C. Atropine
• D. Physostigmine

Answer: (A)

Reversing benzodiazepine effects is achieved with a drug that blocks the benzodiazepine binding site on the GABA_A receptor. Flumazenil acts as a benzodiazepine receptor antagonist, displacing benzodiazepines and rapidly reversing their CNS depressant effects, including sedation and potential respiratory depression.

Naloxone corrects opioid effects by competing at mu receptors, not at the benzodiazepine site. Atropine and physostigmine target the cholinergic system—antimuscarinic and acetylcholinesterase inhibition, respectively—and do not reverse benzodiazepines.

Be mindful that flumazenil can precipitate withdrawal or seizures in people who are benzodiazepine-dependent or who have mixed substance use, so it is used with caution.