Which are examples of short-acting glucocorticoids?

• A. Hydrocortisone and Cortisone
• B. Prednisone and Methylprednisolone
• C. Dexamethasone and Betamethasone
• D. Triamcinolone and Fluticasone

Answer: (A)

The question tests understanding of how long different glucocorticoids act after dosing. Short-acting glucocorticoids produce their effects for about 8–12 hours. Hydrocortisone (cortisol) and cortisone are classic representatives of this group. The other drugs listed have longer durations: prednisone and methylprednisolone are intermediate-acting, dexamethasone and betamethasone are long-acting, and triamcinolone and fluticasone are not short-acting (with triamcinolone intermediate and fluticasone long-acting). Therefore, the best examples of short-acting glucocorticoids are hydrocortisone and cortisone.