Which diagnostic step is used to obtain histopathologic confirmation in these nasal disease cases?

• A. Biopsy
• B. Cytology
• C. Radiography
• D. Ultrasound

Answer: (A)

Histopathologic confirmation requires examining a tissue sample under a microscope to see the architecture of the lesion. That’s what a biopsy provides: a piece of the affected tissue that pathologists can process and study to distinguish tumor types, inflammatory conditions, and other diseases based on how the cells and their organization look.

Cytology, by contrast, studies individual cells and their features, but it doesn’t preserve tissue structure, so it’s often not definitive for histopathology in nasal diseases. Imaging tools like radiography or ultrasound can show where a lesion is and its extent or guide sampling, but they do not yield histologic tissue for microscopic confirmation.