Which glucocorticoid would you give this itchy dog?

• A. Dexamethasone
• B. Betamethasone
• C. Prednisone
• D. Hydrocortisone

Answer: (C)

When a dog has itchy, likely inflammatory dermatitis, you want an oral glucocorticoid that is effective, workable for owners, and has a predictable anti-inflammatory effect. Prednisone fits that need well because it’s given by mouth and is a prodrug that’s converted in the liver to its active form, prednisolone. This conversion reliably provides the anti-inflammatory and immunosuppressive action needed to reduce pruritus, with a dosing plan that’s practical for long-term or short-term use.

The other options aren’t as well suited for a typical itchy dog in this scenario. Dexamethasone and betamethasone are much more potent and long-acting, which increases the risk of side effects and makes them less appropriate for routine management of simple pruritus. Hydrocortisone is comparatively weak in anti-inflammatory potency, so it’s not ideal for systemic itching in dogs. Prednisone offers a balanced, effective option for systemic control of itching in dogs.