Which of the following is an example of a long-acting glucocorticoid?

• A. Dexamethasone
• B. Hydrocortisone
• C. Prednisone
• D. Methylprednisolone

Answer: (A)

Dexamethasone is a long-acting glucocorticoid because it has a prolonged biological half-life and sustained glucocorticoid effect, typically lasting about a day or more. Its strong potency and minimal mineralocorticoid activity mean you get extended anti-inflammatory and immunosuppressive action without significant fluid retention. Other commonly used steroids like hydrocortisone are short-acting, while prednisone and methylprednisolone are intermediate-acting, so they don’t provide as long a duration of effect. Clinically, dexamethasone is chosen when a prolonged anti-inflammatory action is needed or when mineralocorticoid effects are undesirable.